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Merseyside Regional Head and Neck Cancer Centre
How will head or neck cancer affect my life

Research...

Publications

The Merseyside Regional unit has published many academic papers on all aspects of head and neck cancer treatment and its effects.

Click here to search our on-line publications database>

 

Randomised Control Trials / Clinical Trials / Outcome Research

This page has information about the current clinical trials/clinical outcome research being undertaken at Aintree:


 

Head & Neck Oncology Clinical Trials Newsletter

Click here for the Spring 2015 Head and Neck Clinical Trials Newsletter

Autumn 2014 Head and Neck Newsletter

Summer 2014 Head & Neck Studies Newsletter

Christmas 2013 Head & Neck Studies Newsletter

Autumn 2013 Head & Neck Studies Newsletter

Click on the above links for previous editions of the Head & Neck Studies Newsletter


Open and recent studies information spreadsheet

Click on the EXCEL logo for more information on open and recent studies at Aintree

Click here for more information on open and recent studies at Aintree


 

Current Randomised Control Trials:

DAHANCA -21

Click here for the DAHANCA -21 webpage (CRUK)

Aims
This multicenter study aims at estimating the clinical effect of HBO on osteoradionecrosis. Summary of proposed study: 114 patients with mandibular osteoradionecrosis (ORN) stage 2, 3 or 4 are randomised to:
group 1 (30 preoperative and 10 postoperative HBO sessions and surgical intervention)
or group 2 (surgical intervention without HBO).
Each HBO session implies inhalation of 100% oxygen during decompression to 14-15 meters for 90 minutes.
Primary endpoint is healing of bone exposure according to the CTCAE v 3.0 criteria, and is estimated one year after surgery.
Secondary endpoints are quality of life, pain intensity, antibiotics and pain medication, trismus, xerostomia and body mass index.
Clinical evaluations are performed at baseline, 1 week, 1 and 3 months and 1 year after surgery. Copenhagen University Hospital is the main centre. Aarhus, Odense, Liverpool (& other UK units), Gothenburg and Rome are participating centres.br/The study is supported by Danish Cancer Association, Danish Cancer Research Foundation and Danish Dental Association.

HOPON

Pre Operative Hyperbaric Oxygen TrialClick on the Logo for Liverpool University HOPON Webpage

HOPON is a randomised clinical trial to discover the value of hyperbaric oxygen (HBO) in preventing jaw necrosis in long term survivors of head and neck cancer. HBO is an additional intensive treatment for patients and needs additional funding on an individal patient basis. Countered against that is the potentially very serious side effect of osteoradionecrosis. Patients having 'surgical procedures' (extracttions / implants) in the jaw following radiotherapy are invited to be randomised to HBO (20 dives pre-surgery and 10 dives post-surgery) versus standard care.

Click here for PDF article: Hyperbaric oxygen in the management of late radiation injury to the head and neck. Part I: treatment.

Click here for PDF article: Hyperbaric oxygen in the management of late radiation injury to the head and neck. Part II: prevention.

 

Click here for 'LCTU' HOPON information webpagesClick on the Logo for the LCTU Clinical Trials Website.

 


 

SEND

RATIONALE: Surgery may be an effective treatment for oral cancer. It is not yet known whether surgery to remove the tumor and lymph nodes in the neck is more effective than surgery to remove the tumor alone in treating patients with early-stage oral cancer.
PURPOSE: This randomized clinical trial is comparing two types of neck surgery to see how well they work in treating patients with early stage oral cancer
Click here for 'Saving Faces' SEND Webpage Click on the Logo for the 'Saving Faces' 'SEND' webpage


AWARE STUDY
Understanding and Reducing Patient Presentation Delay in Oral Cancer

Oral cancer has a poor survival rate of 56%, partly because patients delay presentation to health professionals after noticing symptoms. Delays of three months are common and lead to a 4.5 times greater probability of later stage cancer. SCC has double the incidence in the most socioeconomically deprived areas and poorer survival.
The research officer for this study is Juliet Bell a Clinical Psychology PHD student and she will be overseen by Stephen Brown and Peter Salmon - clinical Psychologists from Liverpool University and Professor Richard Shaw - Consultant OMFS from Aintree.
Increasing awareness of the AWARE study is evidenced by September 2014 recruiting 6 patients (the best month so far).
The study will retrospectively interview patients with oral cancer (study1); asking them to recall the development and progression of symptoms, their responses to them and the reasoning behind their decision to present or not present. The second part of the study (study 2) will commence 6 months after the first and will be recruiting healthy individuals (matched to patients in the first group) and engaging them in think aloud tasks based on guided scenarios.
The third part of the study (study 3) will feature a preliminary RCT using a scenario method to test the efficacy of an informational intervention.
This study is being funded by the Regional Head and Neck Patient Research Forum.

 

QOL / COHORT Studies


 

Clinical Trials

Cell cycle proteins in laryngeal cancer

This project represents a clinical / pathological / basic science collaboration looks at Epithethial Growth Factor (EGFR) and cyclin D1 expression predict for poor response to treatment with radiotherapy in early stage larynx cancer.

Epigenetic biomarkers in oral cancer

This project looks at using the best of modern technology to assess the status of surgical margins in oral cancer. Molecular assessment of surgical margins may prove far more sensitive that current methods and improve the prescription of adjuvant therapy. This study follows on from a RCSEng research fellowship in 2005/6.

Salivary function

For patients who consent samples of normal submandibular gland tissue taken as part of a routine neck dissection will be tested in the laboratory at Liverpool University to see how they work on at a cellular level. By gaining a better understanding of normal tissue it is hoped that this research will lead to improvement in the care of patients with salivary gland diseases such as Sjogrens syndrome.

Outcomes Research

The impact of chemo-radiotherapy treatment for oro-pharyngeal cancer on patient's and carer's daily life

It is hoped to undertake an in depth evaluation of patient's and carer's daily life undergoing chemo-radiotherapy treatment for oro-pharyngeal cancer. This will lead to a better understanding and a Carepathway to help identify and target support at critical times.

NIHR-CCF RfPB for NIHR Number: PB-PG-0407-13104 Patient Concerns Inventory

This study aims to establish and evaluate a Patient Concerns Inventory that when used in routine out-patient clinic will help patients and carers raise issues of concern and promote multidisciplinary support.

Health related quality of life

There are several studiies that are ongoing and we are really grateful to patients for completing the questionnaires and on occasion attending for interview or participating in a telephone survey. We have recently looked at the issue of intimacy. Also delays in patients self presentation with cancer.

 

CRUK Website

Mersey Head and neck Oncology Research Group

Liverpool Cancer Trials Unit Website

ECMC Homepage